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Vaccines and autism: A thorough review of the evidence (2019 update)The Logic of ScienceOne of the most common concerns that people have about vaccines is that they might cause (or exacerbate) autism. This idea is perpetuated by celebrities and innumerable websites, and it has become …
Next, we have cohort studies that compared autism rates between children who did and did not receive the vaccine being stuided. This is one of the most powerful experimental designs, and these studies were particularly large (Hviid et al. 2019 [657,461 children]; Madsen et al. 2002 [440,654 children]; Anders et al. 2004 [109,863 children]; and Jain et al. 2015 95,727 children]). Take another look at those sample sizes, they are enormous (far larger than any of the anti-vaccine studies), but once again, they did not find any significant differences between vaccinated and unvaccinated children....
Further, there is a meta-analysis with over 1.2 million children (Taylor et al. 2014) which also failed to find evidence of vaccines causing autism.
On the anti-vaccine side, I went through their lists of papers (here, here, and here; 160 papers total), and 33 of them weren’t actually about autism, 82 (over half) weren’t about vaccines, 41 were animal trials or in vitro studies (which are weak designs that have limited applicability to humans, especially for something like autism), 60 were on either a form of mercury that has never been in vaccines or thimerosal (which hasn’t been in childhood vaccines for almost two decades), 9 were case reports/conference abstracts/opinion papers/some other non-research paper, and 37 were non-systematic reviews (only 8 of which were relevant to the topic at hand; some papers were in multiple categories).
Only 14 of the papers were actually studies on humans that are relevant to autism and the current vaccine schedule, but none of those studies are large, all of them were association studies (i.e., they could not show causation, because correlation does not equal causation) and most of them were seriously flawed.